Pearl Therapeutics

Located in Redwood City, California, Pearl Therapeutics is an AstraZeneca company specializing in developing a combination of therapies for the treatment of highly prevalent respiratory diseases.

Totaling 75,000 square feet, Southland Engineering provided HVAC, process piping, and plumbing design services for the three-story facility. Featuring manufacturing, laboratory, and office space, the facility consists of eight manufacturing clean rooms and current good manufacturing practices (cGMP) warehouse space.

Approach & Innovations

To comply with owner and FDA requirements, Southland Engineering provided various specialty process systems, in addition to the FDA validated clean rooms. The design features a purified water system with a validated 80 degrees Celsius one and one-half inch stainless steel distribution loop. The system features zero-static point-of-use valves, meets all standards, and eliminates contaminants. To ensure the highest level of quality control for the critical piping system, Southland Engineering designed the system to be substantially prefabricated.

Southland Engineering provided other specialty process systems, including acid waste neutralization and liquid nitrogen storage and distribution.  Additionally, by providing an opportunity to store and distribute liquid nitrogen, a critical utility for process operations, high purity nitrogen can be stored as a liquid and distributed as a controlled gas.


Client: AstraZeneca

Location: Redwood City, California


Square Footage: 75,000